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Ideally in ?owtriggering, the beginning of the signal shouldcorrespond to when inspiratory ?ow crosses thezero line. Becausethe association cortex is highly specialized, the observedbrain–behavioral associations have been very insightful.Global measures of cognitive decline, such as the mini–mental state examination (MMSE), show a widely distrib-uted pattern of association with cortical atrophy, includ-ing the entorhinal, parahippocampal, precuneal, superiorparietal, and subgenual cingulate association cortices(Apostolova et al., 2006c)

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