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Macrophages that have phagocytosed cellular debris andinhaled environmental pollutants (e.g. dust particles, silica, cigarette tar, andmicroorganisms) in the alveolar lumen migrate back to the alveolar septa,where they remain throughout life.These septal macrophages are seen hereaslarge, irregularly shaped cells loaded with black cytoplasmic inclusions thatobscure the view ofthe nucleus.
Although“dosage conversion ratio” calculations are used by some clinicians, this practice is notrecommended by the manufacturers of the various BoNT products. Phonological specificity of vowelcontrasts at 18-months.
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